Clarification/Follow-up by tropicalstorm on 04/18/07 2:33 am:
not taking antidepressant drugs or taking them irratically can be as bad as taking them. When you go off antidepressants you have to wean off them gradually or you can have just as bad effect.

Clarification/Follow-up by peddler2 on 04/18/07 3:07 am:
Whether or not Prozac increases the risk of suicide is hard to prove. The only people who take it are depressed. It would be very difficult to ever prove, to ever do a properly controlled study.

Clarification/Follow-up by tropicalstorm on 04/18/07 3:17 am:
It is crucial to learn that according to medical research the theory behind this group of drugs is invalid. Known as serotonin reuptake inhibitors. They are designed to block serotonin in the brain, thereby increasing brain levels of this neurotransmitter. Yet for three decades researchers have been intensely interested in serotonin because LSD and PCP produce their psychedelic effects by mimicking serotonin. Elevated serotonin is found in: psychosis or schizophrenia, mood disorders, organic brain disease, mental retardation, autism and Alzheimer's. While low levels of the metabolism of serotonin (which also produces high serotonin), are found in those with: depression, anxiety, suicide, violence, arson, substance abuse, insomnia, violent nightmares, impulsive behavior, reckless driving, exhibitionism, hostility, argumentive behavior, etc. The drugs increase serotonin and decrease the metabolism of serotonin leading to any and all of the above results. This information is extremely crucial for patients and physicians to learn as soon as possible. We have a high rate of use of these drugs nationwide. Raising serotonin and lowering the metabolism of serotonin in such a large number of people can produce very serious, widespread and long term problems for all of society.

So why are we now in the 90's being told that increased serotonin is good for us? Is it because it is good for the pocketbooks of the manufacturers? One manufacturer is running full page newspaper and magazine ads and half hour TV infomercials to bring in over $7 million daily, while on the other hand they are settling Prozac suicide cases for huge amounts of money in exchange for silence from victim's families on the details of those settlements. The silence in the court cases insures that the drug will be allowed to finish out its patent time, thus bringing in the highest possible profits for the company. They know that with $7 million coming in daily, they can afford to settle a large number of lawsuits and still come out "smelling like a rose" financially. Eli Lilly has been sued for Prozac related deaths in numerous state and federal courts with most of these cases being settled or dismissed - many were dismissed due to the unethical manipulation of the Wesbecker verdict (see time line for details).

We have witnessed no decrease in suicide, but increases in murder/suicide, suicide, unwed pregnancies, domestic violence, manic-depression, MS, hypoglycemia, diabetes, bankruptcies, divorce, mothers (parents) killing children, road rage, school shootings, cancer, Chronic Fatigue Syndrome, and fibromyalgia since these serotonergic drugs have become so popular and I relate it directly to the effects of these drugs. The death toll has continued to climb drastically since I wrote PROZAC: PANACEA OR PANDORA? Some of the cases you may be familiar with are: Mr. and Mrs. Phil Hartman (Zoloft), Prozac was found in the van of Mark Barton, the Atlanta day trader, who recently killed his family and others in a shooting spree before taking his own life; Neal Furrow, in LA Jewish school shooting was reported to have been court ordered to be on Prozac along with several other medications; the Salt Lake Family History Library shooting, school shootings in Littleton, Colorado (Luvox), Atlanta, Georgia, Springfield, Oregon (Prozac), and Caldwell, Idaho; another boy in Pocatello, ID in 1998 who in seizure activity from Zoloft had a stand off at the school; 15 year old Chris Shanahan (Paxil) in Rigby, ID who out of the blue killed a woman; the shooting at the lottery in Connecticut last spring by Matthew Beck (Luvox) that left five dead in a murder/suicide; the New York City Subway bombing by Edward Leary (Prozac); little 10 year old Timmy (Prozac) in southern Florida; Nick Mansies (Paxil) in New Jersey who was convicted of killing a little boy who was selling cookies door to door; in Orange County, CA Dana Sue Gray (Paxil) who co-workers described as a very caring nurse killed several elderly people; Officer Stephen Christian (Prozac) one of the finest officers on the Dallas Police force, who ran into a police substation shooting at fellow officers and was killed; 13 year old Chris Fetters (Prozac) in Iowa who killed her favorite aunt; David Rothman (Prozac) killed two co-workers and himself at the Dept. of Agriculture in Ingelwood, CA; Williams Evans (Zoloft) shot one co-worker at the Ohio Bureau of Employment Services before shooting himself in Columbus, OH; Winatchee, WA where 43 people were wrongfully imprisoned in a false accusation of sexual abuse "witch hunt" fury started by a child under the influence of Prozac and Paxil; Christopher Vasquez (Zoloft) killed Michael McMorrow in Central Park; Megan Hogg (Prozac) duct taped the mouths and noses of her three little girls and took a handful of pills; Vera Espinoza (Prozac) in Randolph, VT shot her small son and daughter before shooting herself; an elderly man (Prozac) in Layton, UT axed his wife and daughter to death; Margaret Kastanis (Prozac) used a knife and hammer to kill her three children before stabbing herself to death; an elderly man (Paxil) in Dallas, TX strangled his wife before shooting himself twice in the chest; Larramie Huntzinger (Zoloft) blacked out and ran his car into three young girls killing two in Salt Lake City, UT; Mary Hinkelman (Prozac), a nurse in Baroda, MI shot her two small daughters and her sister before shooting herself; Lisa Fox (Prozac) shot her small son and her dog before shooting herself in Brighton, MI; Debi Louselle (Zoloft) shot daughter and then herself in Salt Lake City, UT; a father in Wyoming shot his wife, daughter and baby grand-daughter then himself after only days on Paxil; a mother (Prozac) in Pleasant Grove, UT killed her 17 year old son with a sledge hammer while he slept before she attempted suicide by drinking draino; Larry Butzz, a superintendent of schools in Ames, IA shot his wife, son and daughter before shooting himself - many cases pending in court are not mentioned. This is only a handful of MANY, MANY more cases - there would not be room for anything else if I continued listing the cases. A few additional famous victims: Princess Di (Prozac) and Dodi Fayed -via their driver Henri Paul (Prozac), Monica Lewinsky (Prozac, Zoloft, Effexor, Serzone and Phen-Fen), Chris Farley (Prozac), Pres. Clinton's ex-partner Jim Mc Dougal (Prozac), Abby Hoffman (Prozac), Del Shannon (Prozac), Danielle Steele's son (Prozac), INXS singer Michael Hutchence (Prozac), Sarah - Dutchess of York (Phen-Fen)

The latest figures show Prozac has about 44,000 adverse reports filed with the FDA. Out of those reports there are about 2500 deaths with the large majority of them linked to suicide or violence. The suicide statistics relating to women are shocking. According to the CDC there are about 30,000 suicides yearly in the United States. Out of those about 6,000 are women - a ratio of about 4.3 to 1, male to female. About twice as many women as men are treated for depression demonstrating that generally men are more than 8 times as lethal in their suicidal gestures as women. Women were known to use less lethal means until the SSRI antidepressants hit the market. But on Prozac and Paxil, women committed 40% of the suicides - many were strikingly violent and clearly leaving no means for rescue. (Remember that because Prozac was the first of this group of drugs its track record gives us a vision of what is to come with other serotonergic antidepressants, especially when they are so powerful in the reuptake of serotonin.)

TIME LINE OF CRITICAL INFORMATION DISCOVERED SINCE THE BOOK:

*NOTE: Any documents beginning with PZ are Lilly documents on Prozac which have been ferreted out by attorneys and are now being used in lawsuits against the drug company. (Christian vs. Eli Lilly, by Vickery & Waldner, Houston, TX) - - Mid 1950's: Dr. Felix Sulman began his research on those who suffer from high serotonin levels because of an inability to metabolize serotonin. He found that serotonin is a stress neuro-hormone leading even rabbits, the most docile of creatures, to be aggressive. He coined the term "serotonin irritation syndrome." He found that those who were unable to break down serotonin would have the levels increase. They "were in effect being poisoned by the serotonin produced by their own bodies, the irritation victims suffered from migraines, hot flashes, irritability, sleeplessness, pains around the heart, difficulty in breathing, a worsening of bronchial complaints, irrational tension and anxiety. . . horrifying nightmares. It also caused his volunteers to sleep badly - that is, always on the edge of consciousness so that they were not properly rested - and to wake after only a few hours of sleep." (sleep apnea) He also found it caused pregnant women to abort. - - October, 1977: Slater, et.al., Inhibition of REM Sleep by Fluoxetine, a Specific Inhibitor of Serotonin Uptake, October 1977, at p. 385 - Prozac was found to affect sleep habits, specifically to suppress deep sleep, which the scientists call REM (rapid eye movement) sleep in cats. By the fourth day of drug treatment the cats receiving the larger doses, which had been friendly for years, began to growl and hiss. . . . After cessation of the drug treatment, the cats returned to their usual friendly behavior in a week or two; those on the higher doses recovering more slowly. - - 1977: [PZ 1298 1999] "A total of six dogs from the high dose group were removed from treatment ... due to severe occurrences of either aggressive behavior, ataxia, or anorexia."] - - July 31, 1978: [PZ1061 1025-28, July 31, 1978] Human subjects began to be used by Lilly in controlled clinical trials. The first group of patients showed no improvement in their depression, but there were a "large number of reports of adverse reactions." The first human to receive Prozac experienced "dystonia resembling an extrapyramidal reaction" - an uncontrollable, Parkinson-like shaking or trembling. - - July 23, 1979 [PZ 1297 969] The clinical studies in depression showed that "some patients have converted from severe depression to agitation within a few days; in one case the agitation was marked and the patient had to be taken off drug. In future studies the use of benzodiazepines to control the agitation will be permitted." - - August 3, 1979: The clinical trials excluded patients who had serious suicidal risk. [E.g. control #001519, IND Protocol No. 14, August 3, 1979; PZ1135 695, July 2, 1986 memorandum of Dr. Wernicke]. - - December 17, 1984: [PZ 65 449, report of Lilly to FDA] Lilly reported to the FDA that benzodiazepines and other sedatives were given with Prozac throughout the clinical trials. This was to help offset the stimulant effect of the drug. In a memorandum of Lilly scientist Charles Beasley [PZ 541 2007-08] issues of "agitation vs. sedation" and concomitant sedative medications like benzodiazepines (to control the agitation) are discussed. Concerns are that agitation in a suicidal patient can induce suicide. - - March 3, 1986 Lilly controlled the flow of information to the FDA and decided that suicide data on Prozac should not be evaluated, "in the safety-update for the FDA the number of suicides and suicide attempts will not be especially evaluated." [PZ 879 1966, March 3, 1986 telex] - - September 12, 1986: German BGA very concerned with the risk of suicide and ultimately approved Prozac on the condition that physicians be warned of the risk of suicide and told to consider using sedatives and closely monitor patients. [PZ 878 1383, report of Lilly consultant Pohlmeier; PZ 2467 299, September 12, 1986] Lilly actually warned physicians in Germany and other countries that this measure "can be necessary" to minimize the risk of suicide, [PZ 1341 402, December 6, 1989 German warning; PZ 2469 490] - - February 7, 1990: In response to the Harvard study, Teicher, et al., Lilly's top scientist, Leigh Thompson, told his fellow executives that "Lilly can go down the tubes if we lose Prozac". [PZ 1941 827, February 7, 1990]. In the ensuing months Dr. Thompson spoke frequently with his principal FDA regulator about the issue, once at 6:15 in the morning. [PZ 391 1959, July 18, 1990]. Lilly later described the man as "our defender". [PZ1941 2256, September 12, 1990] - - May 29, 1990, Lilly added "suicidal ideation" in the section dealing with post-marketing reports. [PZ883 562, July 26, 1990 memorandum] - - September 14, 1990: Contrary to the advice of his staff, Dr. Thompson told the Eli Lilly Board of Directors that suicide and hostile acts were probably, caused by the patients' underlying disorders rather than Prozac. [PZ542 2101, September 14, 1990; PZ4002 889, Board Minutes]. The staff was concerned because they knew that this issue was never studied during the clinical trials. - - September 11, 1990: Note from Dr. Bruce Stadel, Chief of the Epidemiology Branch, attaching an analysis done by Dr. David Graham, Section Chief within the Epidemiology Branch, of Lilly's July 17, 1990 submission to the FDA on the Prozac/suicidality/violence issue. The following factors were (a) brought to the attention of those in the higher echelons of the FDA, but (b) ignored, discounted or "trashed" by them: #1 Lilly's analysis improperly excluded 76 out of 97 suicides; as Dr. Stadel expressed it, "[i]t is inappropriate in a safety analysis to exclude such a large proportion of case" #2 Lilly admitted that its clinical trials "were not designed for the prospective evaluation of suicidality" and that "[i]n these trials, patients with current suicidal ideation were excluded" #3 Lilly admitted that the HAMD-3 rating scale it used to assess suicidality in clinical trials was inadequate; and that Lilly's statements about violence only demonstrated "how great under-reporting is" and that "[t]he actual data showed a higher percentage of treatment-emergent suicidality among fluoxetine (2.9% than tricyclic (0.8%) patients . . . [which percentage] was similar to that reported by Teicher." - - July 1, 1992: A study lead by Dr. Lorne Brandes of the Manatoba Institute of Cell Biology in Winnipeg, Canada was published in CANCER RESEARCH linking the two most popular anti-depressants, Elavil and Prozac to cancer. - - 1993(?): A study headed by Edward Domino showed LSD flashbacks and LSD reactions induced by Prozac. - - June 9, 1994: The New York Review of Books article by Dr. Sherwin Nuland slams Peter Kramer for pushing Prozac in his book Listening to Prozac. He pointed out that all docs are taught in med school this little poem about serotonin: "This man was addicted to moanin', confusion, edema, and groanin', intestinal rushes, great tricolored blushes, and died from too much serotonin." He listed constriction of lungs and intestines, diarrhea, wheezing, flushing, mental confusion, tightening of bronchioles, and lessening conscious control over behavior from increases in serotonin. "Moreover, . . . it is still too early to arrive at a reliable estimate of possible dangers that may appear in the long term," and 15% dropped out of the clinical trials on Prozac because of adverse reactions. He also discussed the similarity of serotonin to the psychedelics like LSD and PCP. - - November, 1994: Krystal JH, Webb E, Cooney N, et al., "Specificity of Ethanol-like Effects Elicited in Serotonergic and Noradrenergic Mechanisms," ARCHIVES OF GENERAL PSYCHIATRY, Vol. 51, Issue 11, pgs 898-911, 1994 demonstrated that an increase in brain levels of either of two neurotransmitters, serotonin or noradrenalin, produces: #1 a craving for alcohol, #2 anger, #3 anxiety. They found this to be especially true for those who have a history of alcoholism. An increase serotonin in turn increases noradrenalin. Numerous reports have been made by reformed alcoholics who are being "driven" to alcohol again after being prescribed a serotonergic drug.